I have an enclosed filling line with different sectors that have different purity classes. The sectors have air short circuits due to their design. The conveyor belt passes through. How is the clean room to be assessed technically? Does the 10Pa pressure difference requirement between the classes/sections also apply here? Very bad: in the last section there must also be negative pressure so that the active ingredient is not inhaled by the personnel. ..

No, in this case it is no longer usual to work with defined pressure differences and alarm limit values, but with flow visualizations and continuous air velocity measurement. With the assumption that the overflow from one zone to the next is ensured with constant volume flows.